Intercellular adhesion molecule

From Proteopedia

Revision as of 10:44, 29 March 2016

spinqualitylabelsall models Structure of glycosylated human ICAM-1 domains 1-2 (grey and pink) complex with LFA-1 (yellow and green) and Mg+2 ion (green) (PDB code 1mq8). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Intercellular adhesion molecule (ICAM) is part of the immunoglobulin superfamily. ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation[1]. ICAM contains 5 Ig-like domains. Disease ICAM mutation is involved i multiple sclerosis[2]. Relevance Structural highlights

3D structures of intercellular adhesion molecule

Updated on 29-March-2016

References

1. ↑ van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl). 1996 Jan;74(1):13-33. PMID:8834767
2. ↑ Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J, Wikstrom J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol. 2003 Mar;64(3):345-9. PMID:12590979