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The Human metabotropic glutamate receptor 5 transmembrane domain is a | The Human metabotropic glutamate receptor 5 transmembrane domain is a | ||
| - | == Structure== | + | == Structure == |
| - | [[Image:STR.png|100 px|left|thumb| | + | [[Image:STR.png|100 px|left|thumb|Cross section view of mavoglurant in the binding pocket]] |
=== Extracellular Domain === | === Extracellular Domain === | ||
| - | === Binding Pocket === | ||
| - | [[Image: Organic with clipped surface.png|100 px|left|thumb|Figure Legend]] | ||
| - | |||
| - | <scene name='72/721532/Mavoglurant_in_pocket/4'>Mavoglurant Mavoglurant is in the 7 Transmembrane Domain Pocket. Also, the lysozyme is attached to the intercellular region of the 7 Transmembrane Domain.</scene> | ||
| - | === Ionic Locks === | ||
| - | This is the <scene name='72/726428/Ionic_lock/2'>Ionic Lock in inactive state</scene>. | ||
This is the <scene name='72/721532/Ecl_trail_1/7'>Extracellular Loops ECL 1, 2, and 3 highlighted in purple</scene> | This is the <scene name='72/721532/Ecl_trail_1/7'>Extracellular Loops ECL 1, 2, and 3 highlighted in purple</scene> | ||
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<scene name='72/721532/Ecl_trail_1/6'>Disulfide Bond The Disulfide bond is attached to Helix 3 and the Amino Acid chain connected to Helix 5 and the N terminus</scene> | <scene name='72/721532/Ecl_trail_1/6'>Disulfide Bond The Disulfide bond is attached to Helix 3 and the Amino Acid chain connected to Helix 5 and the N terminus</scene> | ||
| + | === Binding Pocket === | ||
| + | [[Image: Organic with clipped surface.png|100 px|left|thumb|Figure Legend]] | ||
| + | |||
| + | <scene name='72/721532/Mavoglurant_in_pocket/4'>Mavoglurant Mavoglurant is in the 7 Transmembrane Domain Pocket. Also, the lysozyme is attached to the intercellular region of the 7 Transmembrane Domain.</scene> | ||
== Function and Pathway == | == Function and Pathway == | ||
== Disease == | == Disease == | ||
| - | + | ||
=== Parkinson's === | === Parkinson's === | ||
| - | == Relevance == | ||
| - | |||
| - | == Structural highlights == | ||
| - | |||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
| - | |||
| - | </StructureSection> | ||
| - | == References == | ||
| - | <references/> | ||
Revision as of 13:37, 29 March 2016
Human metabotropic glutamate receptor 5 transmembrane domain
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