Lysine-specific histone demethylase
From Proteopedia
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m (Lysine-specific histone demethylase 1 moved to Lysine-specific histone demethylase: requested by Editor) |
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**[[2h94]], [[2dw4]], [[2z3y]], [[2z5u]], [[4fwe]], [[4fwj]], [[4gu1]] – hLSD1<br /> | **[[2h94]], [[2dw4]], [[2z3y]], [[2z5u]], [[4fwe]], [[4fwj]], [[4gu1]] – hLSD1<br /> | ||
**[[2hko]] – hLSD1 (mutant)<br /> | **[[2hko]] – hLSD1 (mutant)<br /> | ||
| - | **[[2xdp]] – hLSD 4C tudor domain <br /> | ||
| - | **[[2xml]], [[4xdp]] – hLSD 4C catalytic domain <br /> | ||
| - | **[[4xdo]] – hLSD 4C catalytic domain + oxalylglycine <br /> | ||
**[[2ma5]] – hLSD 5B zinc finger domain 3 - NMR<br /> | **[[2ma5]] – hLSD 5B zinc finger domain 3 - NMR<br /> | ||
**[[2mny]] – hLSD 5B zinc finger domain 1 - NMR<br /> | **[[2mny]] – hLSD 5B zinc finger domain 1 - NMR<br /> | ||
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*LSD complex with histone H3 peptide | *LSD complex with histone H3 peptide | ||
| - | **[[4v2v]] – hLSD 4C catalytic domain + histone 3.1 peptide <br /> | ||
**[[2mnz]] – hLSD 5B zinc finger domain 1 + histone 3 peptide - NMR<br /> | **[[2mnz]] – hLSD 5B zinc finger domain 1 + histone 3 peptide - NMR<br /> | ||
**[[4fwf]] – hLSD1 + histone 3.1 peptide<br /> | **[[4fwf]] – hLSD1 + histone 3.1 peptide<br /> | ||
| - | **[[4gu0]] – | + | **[[4gu0]] – hLSD2 + histone 3.3 peptide<br /> |
| - | **[[4gur]], [[4gus]], [[4hsu]] – | + | **[[4gur]], [[4gus]], [[4hsu]] – hLSD2 + histone 3.3 peptide + oxidoreductase<br /> |
*LSD1 complex with CoREST | *LSD1 complex with CoREST | ||
Revision as of 07:11, 5 April 2016
Lysine-specific histone demethylase 1 (LSD1) is a flavin-dependent oxidase that catalyzes the removal of methyl groups from mono- and dimethylated lysine 4 of histone H3. LSD1 is a nuclear homolog of amine oxidase. It functions as histone demethylase and transcriptional corepressor. LSD1 demethylation occurs via a reaction which produces formaldehyde. LSD1 is a component of transcriptional corepressor complex which also contains CoREST (corepressor of element-1-silencing transcription factor).
3D structures of lysine-specific histone demethylase 1
Updated on 05-April-2016
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
