Ketol-acid reductoisomerase
From Proteopedia
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<StructureSection load='3ulk' size='340' side='right' caption='E. coli class II ketol-acid reductoisomerase complex with NADPH, sulfate and Mg+2 ion (PDB code [[3ulk]]) ' scene=''> | <StructureSection load='3ulk' size='340' side='right' caption='E. coli class II ketol-acid reductoisomerase complex with NADPH, sulfate and Mg+2 ion (PDB code [[3ulk]]) ' scene=''> | ||
| - | '''Ketol-acid reductoisomerase''' (KARI) is a bifunctional enzyme which catalizes two steps in the biosynthesis of branched-chain amino acids. KARI catalyzes the isomerization of alkyls and the NADPH-dependent reduction of a 2-ketoacid. There are two forms of KARI. A short form – Class I – found in fungi and most bacteria and a long form – Class II – found in plants. | ||
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== Function == | == Function == | ||
| - | + | '''Ketol-acid reductoisomerase''' (KARI) is a bifunctional enzyme which catalizes two steps in the biosynthesis of branched-chain amino acids. KARI catalyzes the isomerization of alkyls and the NADPH-dependent reduction of a 2-ketoacid<ref>PMID:15654896</ref>. There are two forms of KARI. A short form – '''Class I''' – found in fungi and most bacteria and a long form – '''Class II''' – found in plants. | |
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</StructureSection> | </StructureSection> | ||
Revision as of 10:35, 6 April 2016
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3D Structures of Ketol-acid reductoisomerase
Updated on 06-April-2016
References
- ↑ Tyagi R, Lee YT, Guddat LW, Duggleby RG. Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site. FEBS J. 2005 Jan;272(2):593-602. PMID:15654896 doi:http://dx.doi.org/10.1111/j.1742-4658.2004.04506.x
