Leukotriene B4 hydroxydehydrogenase

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{{STRUCTURE_1zsv| PDB=1zsv | SIZE=400| SCENE=Leukotriene_B4_hydroxydehydrogenase/Cv/1 |right|CAPTION=Leukotriene B4 hydroxydehydrogenase tetramer complex with Cl- ions [[1zsv]]}}
 
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[[Leukotriene B4 hydroxydehydrogenase]] (LB4H) is part of the arachidonic acid cycle and is involved in inflammation.
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<StructureSection load='1v3v' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''>
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== Function ==
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[[Leukotriene B4 hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase]] (LB4H) is a bifunctional enzyme. It is part of the arachidonic acid cycle and is part of the metabolism of prostaglandins, leukotriene B4 and lipoxin. LB4H is san NADP-dependent enzyme.
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== Relevance ==
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LB4H 1 restricts inflammation and confers resistance to tuberculosis infection<ref>PMID:23874453</ref>.
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== Structural highlights ==
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LB4H active site is located at the hydrophobic pore on the dimer interface<ref>PMID:15007077</ref>.
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</StructureSection>
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== Structural highlights ==
== 3D Structures of Leukotriene B4 hydroxydehydrogenase ==
== 3D Structures of Leukotriene B4 hydroxydehydrogenase ==
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[[1v3t]], [[1v3u]] - gpLB4H/15-oxo-prostaglandin 13-reductase<br />
[[1v3t]], [[1v3u]] - gpLB4H/15-oxo-prostaglandin 13-reductase<br />
[[1v3v]] - gpLB4H/15-oxo-prostaglandin 13-reductase+NADP+15-oxo-PGE-2<br />
[[1v3v]] - gpLB4H/15-oxo-prostaglandin 13-reductase+NADP+15-oxo-PGE-2<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:04, 13 April 2016

Human α-defensin 1 (PDB entry 2pm4)

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Structural highlights

3D Structures of Leukotriene B4 hydroxydehydrogenase

1zsv – LB4H - human
2dm6 –gpLB4H/15-oxo-prostaglandin 13-reductase+indomethacin – guinea pig
1v3t, 1v3u - gpLB4H/15-oxo-prostaglandin 13-reductase
1v3v - gpLB4H/15-oxo-prostaglandin 13-reductase+NADP+15-oxo-PGE-2

References

  1. ↑ Tobin DM, Roca FJ, Ray JP, Ko DC, Ramakrishnan L. An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. PLoS One. 2013 Jul 11;8(7):e67828. doi: 10.1371/journal.pone.0067828. Print 2013. PMID:23874453 doi:http://dx.doi.org/10.1371/journal.pone.0067828
  2. ↑ Hori T, Yokomizo T, Ago H, Sugahara M, Ueno G, Yamamoto M, Kumasaka T, Shimizu T, Miyano M. Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop. J Biol Chem. 2004 May 21;279(21):22615-23. Epub 2004 Mar 8. PMID:15007077 doi:10.1074/jbc.M312655200

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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