Lysine-specific histone demethylase
From Proteopedia
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{{STRUCTURE_2v1d| PDB=2v1d | SIZE=400| SCENE=|right|CAPTION=Human FAD-containing LSD1 (grey) complex with CoREST (green) and histone H3 helix (pink), [[2v1d]] }} | {{STRUCTURE_2v1d| PDB=2v1d | SIZE=400| SCENE=|right|CAPTION=Human FAD-containing LSD1 (grey) complex with CoREST (green) and histone H3 helix (pink), [[2v1d]] }} | ||
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| - | + | '''Lysine-specific histone demethylase 1''' (LSD1) is a flavin-dependent oxidase that catalyzes the removal of methyl groups from mono- and dimethylated lysine 4 of histone H3. LSD1 is a nuclear homolog of amine oxidase. It functions as histone demethylase and transcriptional corepressor. LSD1 demethylation occurs via a reaction which produces formaldehyde. LSD1 is a component of transcriptional corepressor complex which also contains CoREST (corepressor of element-1-silencing transcription factor)<ref>PMID:22339659</ref>. | |
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| - | '''Lysine-specific histone demethylase 1''' (LSD1) is a flavin-dependent oxidase that catalyzes the removal of methyl groups from mono- and dimethylated lysine 4 of histone H3. LSD1 is a nuclear homolog of amine oxidase. It functions as histone demethylase and transcriptional corepressor. LSD1 demethylation occurs via a reaction which produces formaldehyde. LSD1 is a component of transcriptional corepressor complex which also contains CoREST (corepressor of element-1-silencing transcription factor). | + | |
==3D structures of lysine-specific histone demethylase 1== | ==3D structures of lysine-specific histone demethylase 1== | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:18, 13 April 2016
Lysine-specific histone demethylase 1 (LSD1) is a flavin-dependent oxidase that catalyzes the removal of methyl groups from mono- and dimethylated lysine 4 of histone H3. LSD1 is a nuclear homolog of amine oxidase. It functions as histone demethylase and transcriptional corepressor. LSD1 demethylation occurs via a reaction which produces formaldehyde. LSD1 is a component of transcriptional corepressor complex which also contains CoREST (corepressor of element-1-silencing transcription factor)[1].
3D structures of lysine-specific histone demethylase 1
Updated on 13-April-2016
References
- ↑ Chen Y, Jie W, Yan W, Zhou K, Xiao Y. Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy. Crit Rev Eukaryot Gene Expr. 2012;22(1):53-9. PMID:22339659
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