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Mannose-binding protein

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{{STRUCTURE_1kzb| PDB=1kzb | SIZE=400| SCENE= |right|CAPTION=Rat mannose-binding protein fragment complex with mannose and Ca+2 ion, [[1kzb]] }}
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{{STRUCTURE_1kzb| PDB=1kzb | SIZE=400| SCENE= |right|CAPTION=Rat mannose-binding protein fragment complex with mannose (stick model) and Ca+2 ion, [[1kzb]] }}
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== Function ==
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'''Mannose-binding protein''' (MBL) is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria, viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, the MASP initiates the complement cascade resulting in lysis of the pathogen<ref>PMID:8528769</ref>.
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== Structural highlights ==
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'''Mannose-binding protein''' (MBL) is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria, viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, the MASP initiates the complement cascade resulting in lysis of the pathogen.
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==3D structures of mannose-binding protein==
==3D structures of mannose-binding protein==
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**[[1kzb]], [[1kzc]] - rMBL fragment + mannose
**[[1kzb]], [[1kzc]] - rMBL fragment + mannose
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:01, 18 April 2016

Template:STRUCTURE 1kzb

Contents

Function

Mannose-binding protein (MBL) is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria, viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, the MASP initiates the complement cascade resulting in lysis of the pathogen[1].

Structural highlights

3D structures of mannose-binding protein

Updated on 18-April-2016

References

  1. ↑ White SH, Wimley WC, Selsted ME. Structure, function, and membrane integration of defensins. Curr Opin Struct Biol. 1995 Aug;5(4):521-7. PMID:8528769

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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