Met repressor
From Proteopedia
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{{STRUCTURE_1mjo| PDB=1mjo | SIZE=400| SCENE= |right|CAPTION=EcMR (mutant) complex with corepressor SAM Ca+2 ion (green) and DNA [[1mjo]] }} | {{STRUCTURE_1mjo| PDB=1mjo | SIZE=400| SCENE= |right|CAPTION=EcMR (mutant) complex with corepressor SAM Ca+2 ion (green) and DNA [[1mjo]] }} | ||
== Function == | == Function == | ||
| - | '''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The | + | '''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The co-repressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis<ref>PMID:8092669</ref>. For additional details see<br /> |
[[Taylor met repressor]]<br /> | [[Taylor met repressor]]<br /> | ||
[[Joe Granger Methionine Repressor: Escherichia coli]]. | [[Joe Granger Methionine Repressor: Escherichia coli]]. | ||
Revision as of 10:58, 20 April 2016
Function
Met repressor (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The co-repressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis[1]. For additional details see
Taylor met repressor
Joe Granger Methionine Repressor: Escherichia coli.
3D Structures of Met repressor
Updated on 20-April-2016
1cmb – EcMR – Escherichia coli
1mjk – EcMR (mutant)
1cma – EcMR + DNA
1mjm – EcMR (mutant) + DNA
1cmc – EcMR + SAM
1mjl, 1mjp – EcMR (mutant) + SAM
1mj2, 1mjo, 1mjq – EcMR (mutant) + SAM + DNA
