CYP3A4
From Proteopedia
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== Overview == | == Overview == | ||
| - | Cytochrome P450 3A4 (CYP3A4) is in the heme-thiolate monooxygenases enzyme group meaning the protein contains a heme group with an iron atom. Enzymes in Cytochrome P450 are oxidizing enzymes and CYP3A4 works in the body oxidizing foreign molecules such as toxins and drugs. It appears almost half of the marketed pharmaceutical drugs are metabolized by CYP3A4 [http://www.pharmacytimes.com/publications/issue/2008/2008-09/2008-09-8687] All Cytochrome P450 are essential enzymes for metabolism and the sub family 3A4 is the most important. [http://www.medsafe.govt.nz/profs/PUArticles/March2014DrugMetabolismCytochromeP4503A4.htm] Primarily found in the liver and intestine, CYP3A4 is localized in the endoplasmic reticulum membrane | + | Cytochrome P450 3A4 (CYP3A4) is in the heme-thiolate monooxygenases enzyme group meaning the protein contains a heme group with an iron atom. Enzymes in Cytochrome P450 are oxidizing enzymes and CYP3A4 works in the body oxidizing foreign molecules such as toxins and drugs. It appears almost half of the marketed pharmaceutical drugs are metabolized by CYP3A4 [http://www.pharmacytimes.com/publications/issue/2008/2008-09/2008-09-8687] All Cytochrome P450 are essential enzymes for metabolism and the sub family 3A4 is the most important. [http://www.medsafe.govt.nz/profs/PUArticles/March2014DrugMetabolismCytochromeP4503A4.htm] Primarily found in the liver and intestine, CYP3A4 is localized in the endoplasmic reticulum membrane [http://www.uniprot.org/uniprot/P08684] and are present in all eukaryotic organisms as well as some prokaryotes [http://pubs.acs.org/doi/full/10.1021/cr020443g]. While CYP3A4's role in drug metabolism are numerous, they are often aiding deactivation through facilitated excretion from the system or by direct inactivation. [https://en.wikipedia.org/wiki/CYP3A4#Tissue_distribution] |
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<Structure load='4NY4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />4N | <Structure load='4NY4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />4N | ||
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| + | == Mechanism == | ||
Revision as of 02:29, 28 April 2016
Overview
Cytochrome P450 3A4 (CYP3A4) is in the heme-thiolate monooxygenases enzyme group meaning the protein contains a heme group with an iron atom. Enzymes in Cytochrome P450 are oxidizing enzymes and CYP3A4 works in the body oxidizing foreign molecules such as toxins and drugs. It appears almost half of the marketed pharmaceutical drugs are metabolized by CYP3A4 [1] All Cytochrome P450 are essential enzymes for metabolism and the sub family 3A4 is the most important. [2] Primarily found in the liver and intestine, CYP3A4 is localized in the endoplasmic reticulum membrane [3] and are present in all eukaryotic organisms as well as some prokaryotes [4]. While CYP3A4's role in drug metabolism are numerous, they are often aiding deactivation through facilitated excretion from the system or by direct inactivation. [5]
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