Netrin
From Proteopedia
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<StructureSection load='4ove' size='340' side='right' caption='Glycosylated mouse netrin-1 complex with Ca+2 and Cl-1 ions (PDB code [[4ove]])' scene=''> | <StructureSection load='4ove' size='340' side='right' caption='Glycosylated mouse netrin-1 complex with Ca+2 and Cl-1 ions (PDB code [[4ove]])' scene=''> | ||
| - | '''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types. | ||
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== Function == | == Function == | ||
| - | + | '''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>. '''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein. | |
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== Relevance == | == Relevance == | ||
| + | Netrin-1 is over-expressed in glioblastoma tumor<ref>PMID:23549787</ref>. Netrin-1 is a therapeutic target in cardiovascular diseases<ref>PMID:26209250</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| + | The N-terminal of netrin-1 is homologous to the N-terminal domains of laminin (LN). | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:42, 8 May 2016
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3D Structures of netrin
Updated on 08-May-2016
References
- ↑ Moore SW, Tessier-Lavigne M, Kennedy TE. Netrins and their receptors. Adv Exp Med Biol. 2007;621:17-31. doi: 10.1007/978-0-387-76715-4_2. PMID:18269208 doi:http://dx.doi.org/10.1007/978-0-387-76715-4_2
- ↑ Ylivinkka I, Hu Y, Chen P, Rantanen V, Hautaniemi S, Nyman TA, Keski-Oja J, Hyytiainen M. Netrin-1-induced activation of Notch signaling mediates glioblastoma cell invasion. J Cell Sci. 2013 Jun 1;126(Pt 11):2459-69. doi: 10.1242/jcs.120022. Epub 2013 Apr, 2. PMID:23549787 doi:http://dx.doi.org/10.1242/jcs.120022
- ↑ Layne K, Ferro A, Passacquale G. Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit? Cardiovasc Res. 2015 Sep 1;107(4):410-9. doi: 10.1093/cvr/cvv201. Epub 2015 Jul, 24. PMID:26209250 doi:http://dx.doi.org/10.1093/cvr/cvv201
