Neuropilin
From Proteopedia
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{{STRUCTURE_2qqm| PDB=2qqm | SIZE=400| SCENE= |right|CAPTION=Human neuropilin-1 glycosylated complex with ethylene glycol and Ca+2 ion, [[2qqm]] }} | {{STRUCTURE_2qqm| PDB=2qqm | SIZE=400| SCENE= |right|CAPTION=Human neuropilin-1 glycosylated complex with ethylene glycol and Ca+2 ion, [[2qqm]] }} | ||
| - | '''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins. There are 2 classes of NRP – NRP-1 and NRP-2.<br /> | + | '''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins<ref>PMID:12613542</ref>. There are 2 classes of NRP – NRP-1 and NRP-2.<br /> |
* '''NRP-1''' has high affinity for semaphorin-3A.<br /> | * '''NRP-1''' has high affinity for semaphorin-3A.<br /> | ||
* '''NRP-2''' has high affinity for semaphorin-3F. | * '''NRP-2''' has high affinity for semaphorin-3F. | ||
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| - | {{TOC limit|limit=2}} | ||
== 3D Structures of Neuropilin == | == 3D Structures of Neuropilin == | ||
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**[[2qqk]], [[2qql]] - hNRP-2 A+B domains + semaphorin-blocking antibody | **[[2qqk]], [[2qql]] - hNRP-2 A+B domains + semaphorin-blocking antibody | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:02, 10 May 2016
Neuropilin (NRP) are neuronal receptors. NRP are co-receptors for semaphorins[1]. There are 2 classes of NRP – NRP-1 and NRP-2.
- NRP-1 has high affinity for semaphorin-3A.
- NRP-2 has high affinity for semaphorin-3F.
3D Structures of Neuropilin
Updated on 10-May-2016
References
- ↑ Romeo PH, Lemarchandel V, Tordjman R. Neuropilin-1 in the immune system. Adv Exp Med Biol. 2002;515:49-54. PMID:12613542
