Neuropilin
From Proteopedia
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| - | {{STRUCTURE_2qqm| PDB=2qqm | SIZE=400| SCENE= |right|CAPTION=Human neuropilin-1 | + | {{STRUCTURE_2qqm| PDB=2qqm | SIZE=400| SCENE= |right|CAPTION=Human glycosylated neuropilin-1 domains A2,B1,B2 complex with ethylene glycol and Ca+2 ion (green) [[2qqm]] }} |
== Function == | == Function == | ||
'''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins<ref>PMID:12613542</ref>. There are 2 classes of NRP – NRP-1 and NRP-2.<br /> | '''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins<ref>PMID:12613542</ref>. There are 2 classes of NRP – NRP-1 and NRP-2.<br /> | ||
Revision as of 10:12, 10 May 2016
Contents |
Function
Neuropilin (NRP) are neuronal receptors. NRP are co-receptors for semaphorins[1]. There are 2 classes of NRP – NRP-1 and NRP-2.
- NRP-1 has high affinity for semaphorin-3A.
- NRP-2 has high affinity for semaphorin-3F.
Relevance
NRP are highly expressed in human neoplasms[2].
3D Structures of Neuropilin
Updated on 10-May-2016
References
- ↑ Romeo PH, Lemarchandel V, Tordjman R. Neuropilin-1 in the immune system. Adv Exp Med Biol. 2002;515:49-54. PMID:12613542
- ↑ Pellet-Many C, Frankel P, Jia H, Zachary I. Neuropilins: structure, function and role in disease. Biochem J. 2008 Apr 15;411(2):211-26. doi: 10.1042/BJ20071639. PMID:18363553 doi:http://dx.doi.org/10.1042/BJ20071639
