Neuropilin

(Difference between revisions)

Revision as of 10:29, 10 May 2016

Neuropilin (NRP) are neuronal receptors. NRP are co-receptors for semaphorins^[1]. There are 2 classes of NRP – NRP-1 and NRP-2.

NRP are highly expressed in human neoplasms^[2].

Updated on 10-May-2016

↑ Romeo PH, Lemarchandel V, Tordjman R. Neuropilin-1 in the immune system. Adv Exp Med Biol. 2002;515:49-54. PMID:12613542
↑ Pellet-Many C, Frankel P, Jia H, Zachary I. Neuropilins: structure, function and role in disease. Biochem J. 2008 Apr 15;411(2):211-26. doi: 10.1042/BJ20071639. PMID:18363553 doi:http://dx.doi.org/10.1042/BJ20071639

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 *NRP-1
-**[[1kex]], [[2qqi]] – hNRP-1 B domain – human
+**[[1kex]] – hNRP-1 B1 domain – human
-**[[2qqm]] - hNRP-1 A+B domain<br />
+**[[2qqm]] - hNRP-1 A2+B1+B2 domains<br />
-**[[4deq]] - hNRP-1 B domain + VEGF-A heparin-binding domain<br />
+**[[4deq]] - hNRP-1 B1 domain + VEGF-A heparin-binding domain<br />
-**[[2qqn]] - hNRP-1 B domain + VEGF-blocking antibody
+**[[2qqn]] - hNRP-1 B1 domain + VEGF-blocking antibody
-**[[3i97]] - hNRP-1 B domains + inhibitor
+**[[3i97]] - hNRP-1 B1 domains + inhibitor
-**[[2orx]] – rNRP-1 C1+C2 domains – rat
+**[[2orx]] – rNRP-1 B domains – rat
-**[[2orz]] – rNRP-1 + tuftsin peptide<br />
+**[[2orz]] – rNRP-1 B domains + tuftsin peptide<br />
-**[[4gz9]] - mNRP-1 A+B domain – mouse<br />
+**[[4gz9]] - mNRP-1 A1+A2+B1+B2 domain – mouse<br />
-**[[4gza]] - mNRP-1 A+B domain + plexin A2 + semaphorin 3A
+**[[4gza]] - mNRP-1 A1+A2+B1+B2 domains + plexin A2 + semaphorin 3A
 *NRP-2
-**[[2qqj]], [[4qdq]], [[4qds]] - hNRP-2 B domain<br />
+**[[4qdq]], [[4qds]] - hNRP-2 B1+B2 domains<br />
-**[[4qdr]] - hNRP-2 B domain (mutant)<br />
+**[[2qqj]] - hNRP-2 B1+B2 domains<br />
-**[[2qqo]] - hNRP-2 A+B domains
+**[[4qdr]] - hNRP-2 B1+B2 domain (mutant)<br />
+**[[2qqo]] - hNRP-2 A2+B1+B2 domains
 **[[2qqk]], [[2qql]] - hNRP-2 A+B domains + semaphorin-blocking antibody