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Revision as of 17:12, 10 May 2016

Contents 1 Growth Hormone Releasing Hormone 1.1 Introduction 1.2 Function 1.3 Structural Features 1.4 GHRH Receptor 1.5 Medical Implications 1.6 References

Growth Hormone Releasing Hormone

Introduction

Growth hormone releasing hormone (GHRH) is a secretory neurohormone that causes growth hormone to be released from the pituitary gland. It is naturally produced in the arcuate nucleus of the hypothalamus. The hormone is produced as a 44 amino acid peptide hormone, and first appears in the hypothalamus between 18 and 29 weeks of gestation, corresponding to the initial production of growth hormone by the fetus ^[1]. Growth hormone is required for normal fetal and post fetal development, including bone growth and the regulation of protein production and the metabolism of lipids and carbohydrates ^[2].

spinqualitylabelsall models Growth Hormone-Releasing Hormone, modelled using Phyre modelling engine[1] Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Function

Structural Features

GHRH Receptor

Medical Implications

References

1. ↑ Chawla RK, Parks JS, Rudman D. Structural variants of human growth hormone: biochemical, genetic, and clinical aspects. Annu Rev Med. 1983;34:519-47. PMID:6344776 doi:http://dx.doi.org/10.1146/annurev.me.34.020183.002511
2. ↑ Tang SS, Zhang JH, Du MH, Wu J, Liu JJ. Construction and activity of a novel GHRH analog, Pro-Pro-hGHRH(1-44)-Gly-Gly-Cys. Acta Pharmacol Sin. 2004 Nov;25(11):1464-70. PMID:15525469