1iaj
From Proteopedia
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|PDB= 1iaj |SIZE=350|CAPTION= <scene name='initialview01'>1iaj</scene>, resolution 2.80Å | |PDB= 1iaj |SIZE=350|CAPTION= <scene name='initialview01'>1iaj</scene>, resolution 2.80Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span> |
|GENE= CHAK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= CHAK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1ia9|1IA9]], [[1iah|1IAH]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iaj OCA], [http://www.ebi.ac.uk/pdbsum/1iaj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1iaj RCSB]</span> | ||
}} | }} | ||
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[[Category: Nairn, A C.]] | [[Category: Nairn, A C.]] | ||
[[Category: Yamaguchi, H.]] | [[Category: Yamaguchi, H.]] | ||
| - | [[Category: ZN]] | ||
[[Category: alpha/beta]] | [[Category: alpha/beta]] | ||
[[Category: atp-grasp fold]] | [[Category: atp-grasp fold]] | ||
[[Category: protein kinase like fold]] | [[Category: protein kinase like fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:16:59 2008'' |
Revision as of 18:17, 30 March 2008
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| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | CHAK (Mus musculus) | ||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Related: | 1IA9, 1IAH
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (APO)
Overview
Transient receptor potential (TRP) channels modulate calcium levels in eukaryotic cells in response to external signals. A novel transient receptor potential channel has the ability to phosphorylate itself and other proteins on serine and threonine residues. The catalytic domain of this channel kinase has no detectable sequence similarity to classical eukaryotic protein kinases and is essential for channel function. The structure of the kinase domain, reported here, reveals unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains. The inclusion of the channel kinase catalytic domain within the eukaryotic protein kinase superfamily indicates a significantly wider distribution for this group of signaling proteins than suggested previously by sequence comparisons alone.
About this Structure
1IAJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity., Yamaguchi H, Matsushita M, Nairn AC, Kuriyan J, Mol Cell. 2001 May;7(5):1047-57. PMID:11389851
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