4zij
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of E.Coli DsbA in complex with 2-(4-iodophenylsulfonamido) benzoic acid== | |
| - | + | <StructureSection load='4zij' size='340' side='right' caption='[[4zij]], [[Resolution|resolution]] 1.78Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zij]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZIJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SFQ:2-{[(4-IODOPHENYL)SULFONYL]AMINO}BENZOIC+ACID'>SFQ</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zij OCA], [http://pdbe.org/4zij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zij RCSB], [http://www.ebi.ac.uk/pdbsum/4zij PDBsum]</span></td></tr> |
| - | [[Category: Ilyichova, O | + | </table> |
| - | [[Category: Scanlon, M | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI]] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ilyichova, O V]] | ||
| + | [[Category: Scanlon, M J]] | ||
[[Category: Vazirani, M]] | [[Category: Vazirani, M]] | ||
| + | [[Category: Disulfide oxidoreductase]] | ||
| + | [[Category: Dsba]] | ||
| + | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
| + | [[Category: Redox protein]] | ||
Revision as of 17:02, 15 May 2016
Crystal structure of E.Coli DsbA in complex with 2-(4-iodophenylsulfonamido) benzoic acid
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