This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Nitroreductase
From Proteopedia
(Difference between revisions)
| Line 5: | Line 5: | ||
== Relevance == | == Relevance == | ||
| - | NR is of special interest due to its potential use as activator of prodrugs in cancer therapy<ref>PMID:26431849</ref>. | + | NR is of special interest due to its potential use as activator of prodrugs in cancer therapy<ref>PMID:26431849</ref>. |
== Structural highlights == | == Structural highlights == | ||
| - | NR cofactor FMN is bound to one subunit while the ligand - nicotinic acid - interacts with both subunits. | + | NR <scene name='48/489319/Cv/2'>cofactor FMN is bound directly to one subunit</scene> while the <scene name='48/489319/Cv/3'>ligand - nicotinic acid - interacts with both subunits</scene>. Water molecules shown as red spheres. |
</StructureSection> | </StructureSection> | ||
Revision as of 08:11, 31 May 2016
| |||||||||||
3D structures of nitroreductase
Updated on 31-May-2016
References
- ↑ Lovering AL, Hyde EI, Searle PF, White SA. The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution. J Mol Biol. 2001 May 25;309(1):203-13. PMID:11491290 doi:10.1006/jmbi.2001.4653
- ↑ Williams EM, Little RF, Mowday AM, Rich MH, Chan-Hyams JV, Copp JN, Smaill JB, Patterson AV, Ackerley DF. Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility. Biochem J. 2015 Oct 15;471(2):131-53. doi: 10.1042/BJ20150650. PMID:26431849 doi:http://dx.doi.org/10.1042/BJ20150650
