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1w4r
From Proteopedia
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Revision as of 13:32, 5 November 2007
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STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP
Overview
The structure of human cytosolic thymidine kinase in complex with its, feedback inhibitor 2'-deoxythymidine-5'-triphosphate was determined. This, structure is the first representative of the type II thymidine kinases, found in several pathogens. The structure deviates strongly from the known, structures of type I thymidine kinases such as the Herpes simplex enzyme., It contains a zinc-binding domain with four cysteines complexing a, structural zinc ion. Interestingly, the backbone atoms of the type II, enzyme bind thymine via hydrogen-bonds, in contrast to type I, where side, chains are involved. This results in a specificity difference exploited, for antiviral therapy. The presented structure will foster the development, of new drugs and prodrugs for numerous therapeutic applications.
About this Structure
1W4R is a Single protein structure of sequence from Homo sapiens with ZN, TTP and DTU as ligands. Active as Thymidine kinase, with EC number 2.7.1.21 Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Structure of a type II thymidine kinase with bound dTTP., Birringer MS, Claus MT, Folkers G, Kloer DP, Schulz GE, Scapozza L, FEBS Lett. 2005 Feb 28;579(6):1376-82. PMID:15733844
Page seeded by OCA on Mon Nov 5 15:38:17 2007
Categories: Homo sapiens | Single protein | Thymidine kinase | Birringer, M.S. | Claus, M.T. | Folkers, G. | Kloer, D.P. | Scapozza, L. | Schulz, G.E. | DTU | TTP | ZN | Cytosolic | Human | Kinase | Phosphorylation | Transferase | Type ii
