1iv5
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1g8q|1G8Q]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv5 OCA], [http://www.ebi.ac.uk/pdbsum/1iv5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1iv5 RCSB]</span> | ||
}} | }} | ||
| Line 32: | Line 35: | ||
[[Category: five helix]] | [[Category: five helix]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:25:03 2008'' |
Revision as of 18:25, 30 March 2008
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| , resolution 2.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Related: | 1G8Q
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
New Crystal Form of Human CD81 Large Extracellular Loop.
Overview
The large extracellular loop of human CD81, a tetraspanin mediating hepatitis C virus envelope protein E2 binding to human cells, has been crystallized in a hexagonal form. The three-dimensional structure, solved and refined at 2.6 A resolution (R-factor = 22.8%), shows that the protein adopts a dimeric assembly, based on an association interface built up by tetraspanin-conserved residues. Structural comparisons with the tertiary structure of human CD81 large extracellular loop, previously determined in a different crystal form, show marked conformational fluctuations in the molecular regions thought to be involved in binding to the viral protein, suggesting rules for recognition and assembly within the tetraspan web.
About this Structure
1IV5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop., Kitadokoro K, Ponassi M, Galli G, Petracca R, Falugi F, Grandi G, Bolognesi M, Biol Chem. 2002 Sep;383(9):1447-52. PMID:12437138
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