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1ivu
From Proteopedia
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|PDB= 1ivu |SIZE=350|CAPTION= <scene name='initialview01'>1ivu</scene>, resolution 1.9Å | |PDB= 1ivu |SIZE=350|CAPTION= <scene name='initialview01'>1ivu</scene>, resolution 1.9Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CU:COPPER (II) ION'>CU</scene> | + | |LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Amine_oxidase_(copper-containing) Amine oxidase (copper-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Amine_oxidase_(copper-containing) Amine oxidase (copper-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1av4|1AV4]], [[1avk|1AVK]], [[1avl|1AVL]], [[1iqx|1IQX]], [[1iqy|1IQY]], [[1iu7|1IU7]], [[1ivv|1IVV]], [[1ivw|1IVW]], [[1ivx|1IVX]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ivu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ivu OCA], [http://www.ebi.ac.uk/pdbsum/1ivu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ivu RCSB]</span> | ||
}} | }} | ||
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[[Category: Yamaguchi, H.]] | [[Category: Yamaguchi, H.]] | ||
[[Category: Yoshimura, M.]] | [[Category: Yoshimura, M.]] | ||
| - | [[Category: CU]] | ||
[[Category: amine oxidase]] | [[Category: amine oxidase]] | ||
[[Category: biogenesis]] | [[Category: biogenesis]] | ||
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[[Category: tpq]] | [[Category: tpq]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:25:22 2008'' |
Revision as of 18:25, 30 March 2008
| |||||||
| , resolution 1.9Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Amine oxidase (copper-containing), with EC number 1.4.3.6 | ||||||
| Related: | 1AV4, 1AVK, 1AVL, 1IQX, 1IQY, 1IU7, 1IVV, 1IVW, 1IVX
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of copper amine oxidase from Arthrobacter globiformis: Initial intermediate in topaquinone biogenesis
Overview
The quinone cofactor TPQ in copper amine oxidase is generated by posttranslational modification of an active site tyrosine residue. Using X-ray crystallography, we have probed the copper-dependent autooxidation process of TPQ in the enzyme from Arthrobacter globiformis. Apo enzyme crystals were anaerobically soaked with copper; the structure determined from this crystal provides a view of the initial state: the unmodified tyrosine coordinated to the bound copper. Exposure of the copper-bound crystals to oxygen led to the formation of freeze-trapped intermediates; structural analyses indicate that these intermediates contain dihydroxyphenylalanine quinone and trihydroxyphenylalanine. These are the first visualized intermediates during TPQ biogenesis in copper amine oxidase.
About this Structure
1IVU is a Single protein structure of sequence from Arthrobacter globiformis. Full crystallographic information is available from OCA.
Reference
X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase., Kim M, Okajima T, Kishishita S, Yoshimura M, Kawamori A, Tanizawa K, Yamaguchi H, Nat Struct Biol. 2002 Aug;9(8):591-6. PMID:12134140
Page seeded by OCA on Sun Mar 30 21:25:22 2008
Categories: Amine oxidase (copper-containing) | Arthrobacter globiformis | Single protein | Kawamori, A. | Kim, M. | Kishishita, S. | Okajima, T. | Tanizawa, K. | Yamaguchi, H. | Yoshimura, M. | Amine oxidase | Biogenesis | Copper | Freeze-trapp | Intermediate | Oxidoreductase | Quinone cofactor | Tpq
