Ornithine carbamoyltransferase
From Proteopedia
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='2i6u' size='350' side='right' caption='Structure of ornithine carbamoyltransferase complex with carbamoyl phosphate, sulfate and the competitive inhibitor norvaline (PDB entry [[2i6u]])' scene=''> | |
| - | <StructureSection load='2i6u' size='350' side='right' caption='Structure of ornithine carbamoyltransferase complex with carbamoyl phosphate and the competitive inhibitor norvaline (PDB entry [[2i6u]])' scene=''> | + | |
== Function == | == Function == | ||
| Line 10: | Line 9: | ||
== Structural highlights == | == Structural highlights == | ||
| + | OTC structure contains an N-terminal - carbamoyl phosphate binding domain and a C-terminal - ornithine binding domain. OCT active site is situated between the two domains<ref>PMID:18062991</ref>. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of ornithine carbamoyltransferase== | ==3D structures of ornithine carbamoyltransferase== | ||
Revision as of 09:53, 9 June 2016
| |||||||||||
3D structures of ornithine carbamoyltransferase
Updated on 09-June-2016
1a1s, 1pvv – OTC – Pyrococcus furiosus
2ef0 – OTC – Thermus thermophilus
2p2g – MtOTC – Mycobacterium tuberculosis
3gd5 – OTC – Gleobacter violaceus
3grf – OTC – Giardia intestinalis
3tpf – OTC – Campylobacter jejuni
3upd, 4kwt – VvOTC – Vibrio vulnificus
4ep1 – BaOTC (mutant) – Bacillus anthracis
1akm – EcOTC – Escherichia coli
1dxh – PaOTC – Pseudomonas aeruginosa
1ort – PaOTC (mutant)
2w37 – OTC – Lactobacillus hilgardii
3sds – OTC – valley fever fungus
4amu, 4anf – OTC – Mycoplasma penetrans
4oh7 – OTC – Brucella melitensis
Ornithine carbamoyltransferase complex
1vlv – OTC + phosphate – Thermotoga maritima
2i6u – MtOTC + norvaline + carbamoyl phosphate
4f2g – OTC + phosphate – Burkholderia thailandensis
4h31 – VvOTC + norvaline + carbamoyl phosphate
4jfr – VvOTC + carbamoyl phosphate
4jhx – VvOTC + arginine + carbamoyl phosphate
4jqo – VvOTC + citrulline + phosphate
4nf2 – BaOTC (mutant) + norvaline + carbamoyl phosphate
1c9y – hOTC + norvaline + carbamoyl phosphate - human
1ep9, 1fvo – hOTC + carbamoyl phosphate
1oth – hOTC + ornithine derivative
1duv, 2otc – EcOTC + ornithine derivative
1fb5 – sOTC + norvaline - sheep
References
- ↑ Murata LB, Schachman HK. Structural similarity between ornithine and aspartate transcarbamoylases of Escherichia coli: characterization of the active site and evidence for an interdomain carboxy-terminal helix in ornithine transcarbamoylase. Protein Sci. 1996 Apr;5(4):709-18. PMID:8845761 doi:http://dx.doi.org/10.1002/pro.5560050416
- ↑ Sankaranarayanan R, Cherney MM, Cherney LT, Garen CR, Moradian F, James MN. The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism. J Mol Biol. 2008 Jan 25;375(4):1052-63. Epub 2007 Nov 19. PMID:18062991 doi:10.1016/j.jmb.2007.11.025
