Ornithine carbamoyltransferase

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
*Ornithine carbamoyltransferase
*Ornithine carbamoyltransferase
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*Catabolic ornithine carbamoyltransferase
*Catabolic ornithine carbamoyltransferase
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**[[1dxh]] – PaOTC – Pseudomonas aeruginosa<br />
+
**[[1dxh]] – PaOTC – ''Pseudomonas aeruginosa''<br />
**[[1ort]] – PaOTC (mutant) <br />
**[[1ort]] – PaOTC (mutant) <br />
-
**[[2w37]] – OTC – Lactobacillus hilgardii<br />
+
**[[2w37]] – OTC – ''Lactobacillus hilgardii''<br />
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**[[4amu]], [[4anf]] – OTC – Mycoplasma penetrans<br />
+
**[[4amu]], [[4anf]] – OTC – ''Mycoplasma penetrans''<br />
-
**[[4oh7]] – OTC – Brucella melitensis<br />
+
**[[4oh7]] – OTC – ''Brucella melitensis''<br />
*Anabolic ornithine carbamoyltransferase
*Anabolic ornithine carbamoyltransferase
**[[4kwt]] – VvOTC <br />
**[[4kwt]] – VvOTC <br />
-
**[[4ep1]] – BaOTC (mutant) – Bacillus anthracis<br />
+
**[[4ep1]] – BaOTC (mutant) – ''Bacillus anthracis''<br />
-
**[[3tpf]] – OTC – Campylobacter jejuni<br />
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**[[3tpf]] – OTC – ''Campylobacter jejuni''<br />
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**[[1akm]] – EcOTC – Escherichia coli<br />
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**[[1akm]] – EcOTC – ''Escherichia coli''<br />
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*Ornithine carbamoyltransferase complex
*Ornithine carbamoyltransferase complex
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**[[1vlv]] – OTC + phosphate – ''Thermotoga maritima''<br />
**[[1vlv]] – OTC + phosphate – ''Thermotoga maritima''<br />
**[[2i6u]] – MtOTC + norvaline + carbamoyl phosphate <br />
**[[2i6u]] – MtOTC + norvaline + carbamoyl phosphate <br />
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[[4f2g]] – OTC + phosphate – ''Burkholderia thailandensis''<br />
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**[[4f2g]] – OTC + phosphate – ''Burkholderia thailandensis''<br />
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[[4h31]] – VvOTC + norvaline + CP<br />
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**[[1c9y]] – hOTC + norvaline + carbamoyl phosphate - human<br />
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[[4jfr]] – VvOTC + CP<br />
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**[[1ep9]], [[1fvo]] – hOTC + CP <br />
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[[4jhx]] – VvOTC + arginine + CP<br />
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**[[1oth]] – hOTC + ornithine derivative<br />
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[[4jqo]] – VvOTC + citrulline + phosphate<br />
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**[[1duv]], [[2otc]] – EcOTC + ornithine derivative<br />
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[[4nf2]] – BaOTC (mutant) + norvaline + CP<br />
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**[[1fb5]] – sOTC + norvaline - sheep<br />
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[[1c9y]] – hOTC + norvaline + carbamoyl phosphate - human<br />
+
 
-
[[1ep9]], [[1fvo]] – hOTC + CP <br />
+
*Anabolic ornithine carbamoyltransferase complex
-
[[1oth]] – hOTC + ornithine derivative<br />
+
 
-
[[1duv]], [[2otc]] – EcOTC + ornithine derivative<br />
+
**[[4h31]] – VvOTC + norvaline + carbamoyl phosphate<br />
-
[[1fb5]] – sOTC + norvaline - sheep<br />
+
**[[4jfr]] – VvOTC + carbamoyl phosphate<br />
 +
**[[4jhx]] – VvOTC + arginine + carbamoyl phosphate<br />
 +
**[[4jqo]] – VvOTC + citrulline + phosphate<br />
 +
**[[4nf2]] – BaOTC (mutant) + norvaline + carbamoyl phosphate<br />
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}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:00, 13 June 2016

Structure of ornithine carbamoyltransferase complex with carbamoyl phosphate, sulfate and the competitive inhibitor norvaline (PDB entry 2i6u)

Drag the structure with the mouse to rotate

3D structures of ornithine carbamoyltransferase

Updated on 13-June-2016

References

  1. ↑ Murata LB, Schachman HK. Structural similarity between ornithine and aspartate transcarbamoylases of Escherichia coli: characterization of the active site and evidence for an interdomain carboxy-terminal helix in ornithine transcarbamoylase. Protein Sci. 1996 Apr;5(4):709-18. PMID:8845761 doi:http://dx.doi.org/10.1002/pro.5560050416
  2. ↑ Storkanova G, Vlaskova H, Chuzhanova N, Zeman J, Stranecky V, Majer F, Peskova K, Luksan O, Jirsa M, Hrebicek M, Dvorakova L. Ornithine carbamoyltransferase deficiency: molecular characterization of 29 families. Clin Genet. 2013 Dec;84(6):552-9. doi: 10.1111/cge.12085. Epub 2013 Feb 7. PMID:23278509 doi:http://dx.doi.org/10.1111/cge.12085
  3. ↑ Sankaranarayanan R, Cherney MM, Cherney LT, Garen CR, Moradian F, James MN. The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism. J Mol Biol. 2008 Jan 25;375(4):1052-63. Epub 2007 Nov 19. PMID:18062991 doi:10.1016/j.jmb.2007.11.025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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