Pantothenate kinase

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== Disease ==
== Disease ==
Mutations in PanK II cause the autosomal-recessive disorder Pantothenate kinase-associated neurodegeneration<ref>PMID:15911822</ref>.
Mutations in PanK II cause the autosomal-recessive disorder Pantothenate kinase-associated neurodegeneration<ref>PMID:15911822</ref>.
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== Structural highlights ==
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Pantothenate binds in a buried pocket at the PanK dimer interface<ref>PMID:16905099</ref>.
==3D structures of pantothenate kinase==
==3D structures of pantothenate kinase==

Revision as of 07:50, 14 June 2016

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Contents

Function

Pantothenate kinase (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis[1].

Three types of PanK are known.

  • PanK I found in bacteria
  • PanK II found mostly in eukaryotes
  • PanK III found in bacteria and known as CoaX.

Disease

Mutations in PanK II cause the autosomal-recessive disorder Pantothenate kinase-associated neurodegeneration[2].

Structural highlights

Pantothenate binds in a buried pocket at the PanK dimer interface[3].

3D structures of pantothenate kinase

Updated on 14-June-2016

References

  1. ↑ . PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959
  2. ↑ Pellecchia MT, Valente EM, Cif L, Salvi S, Albanese A, Scarano V, Bonuccelli U, Bentivoglio AR, D'Amico A, Marelli C, Di Giorgio A, Coubes P, Barone P, Dallapiccola B. The diverse phenotype and genotype of pantothenate kinase-associated neurodegeneration. Neurology. 2005 May 24;64(10):1810-2. PMID:15911822 doi:http://dx.doi.org/10.1212/01.WNL.0000161843.52641.EC
  3. ↑ Hong BS, Yun MK, Zhang YM, Chohnan S, Rock CO, White SW, Jackowski S, Park HW, Leonardi R. Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties. Structure. 2006 Aug;14(8):1251-61. PMID:16905099 doi:10.1016/j.str.2006.06.008

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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