Pantothenate synthetase
From Proteopedia
(Difference between revisions)
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| - | {{STRUCTURE_2a7x| PDB=2a7x | SIZE=400| SCENE= |right|CAPTION=Pantothenate synthetase complex with AMP (stick model), sulfate and glycerol [[2a7x]] }} | ||
| - | '''Pantothenate synthetase''' (PS) catalyzes the ATP-dependent condensation of pantoate and β-alanine to form pantothenate. Pantothenate (vitamin B5) biosynthesis is essential for the virulence of Mycobacterium tuberculosis thus its blockage can be used as a potential drug target. | + | <StructureSection load='3uy4' size='350' side='right' caption='Pantothenate synthetase complex with AMP (stick model), sulfate and glycerol (PDB entry [[3uy4]])' scene=''> |
| + | == Function == | ||
| + | '''Pantothenate synthetase''' (PS) catalyzes the ATP-dependent condensation of pantoate and β-alanine to form pantothenate. | ||
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| + | == Relevance == | ||
| + | Pantothenate (vitamin B5) biosynthesis is essential for the virulence of ''Mycobacterium tuberculosis'' thus its blockage can be used as a potential drug target. | ||
==3D structures of pantothenate synthetase== | ==3D structures of pantothenate synthetase== | ||
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**[[1n2b]], [[1n2e]] – MtPS + pantoate + AMPCPP | **[[1n2b]], [[1n2e]] – MtPS + pantoate + AMPCPP | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:22, 14 June 2016
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