PDZ and LIM domain protein
From Proteopedia
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'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]]. | '''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]]. | ||
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| + | *'''PDLIM1''' promotes cell attachment at the cytoskeleton.<br /> | ||
| + | *'''PDLIM2''' may have a role in bringing proteins to the cytoskeleton.<br /> | ||
| + | *'''PDLIM5''' has important role in heart development by scaffolding PKC to the Z-disk region.<br /> | ||
| + | *'''PDLIM7''' is an adaptor protein localizing the LIM-binding proteins to muscle tissues.<br /> | ||
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| + | == Relevance == | ||
| + | PDLIM2 may contribute to cancer cells migratory capacity. PDLIM5 overexpression promotes the development of heart hypertrophy.<br /> | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:13, 15 June 2016
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3D structures of PDZ and LIM domain protein
Updated on 15-June-2016
