This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5fvj
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvj OCA], [http://pdbe.org/5fvj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fvj RCSB], [http://www.ebi.ac.uk/pdbsum/5fvj PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvj OCA], [http://pdbe.org/5fvj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fvj RCSB], [http://www.ebi.ac.uk/pdbsum/5fvj PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The recalcitrance of many bacterial infections to antibiotic treatment is thought to be due to the presence of persisters that are non-growing, antibiotic-insensitive cells. Eventually, persisters resume growth, accounting for relapses of infection. Salmonella is an important pathogen that causes disease through its ability to survive inside macrophages. After macrophage phagocytosis, a significant proportion of the Salmonella population forms non-growing persisters through the action of toxin-antitoxin modules. Here we reveal that one such toxin, TacT, is an acetyltransferase that blocks the primary amine group of amino acids on charged tRNA molecules, thereby inhibiting translation and promoting persister formation. Furthermore, we report the crystal structure of TacT and note unique structural features, including two positively charged surface patches that are essential for toxicity. Finally, we identify a detoxifying mechanism in Salmonella wherein peptidyl-tRNA hydrolase counteracts TacT-dependent growth arrest, explaining how bacterial persisters can resume growth. | ||
| + | |||
| + | A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA.,Cheverton AM, Gollan B, Przydacz M, Wong CT, Mylona A, Hare SA, Helaine S Mol Cell. 2016 May 31. pii: S1097-2765(16)30139-3. doi:, 10.1016/j.molcel.2016.05.002. PMID:27264868<ref>PMID:27264868</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5fvj" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 15:42, 23 June 2016
Crystal structure of TacT
| |||||||||||
