Phosphoribosylaminoimidazole carboxylase
From Proteopedia
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<StructureSection load='1d7a' size='350' side='right' caption='Structure of E. coli PurE octamer complex with 5-aminoimidazole ribonucleotide (AIR) (PDB entry [[1d7a]])' scene=''> | <StructureSection load='1d7a' size='350' side='right' caption='Structure of E. coli PurE octamer complex with 5-aminoimidazole ribonucleotide (AIR) (PDB entry [[1d7a]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Phosphoribosylaminoimidazole carboxylase (PurE)''' is part of the purine biosynthesis and catalyses the reversible conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 5-aminoimidazole ribonucleotide (AIR). In E. coli PurE is an independent enzyme while in plants and fungi it is a domain of phosphoribosylaminoimidazole carboxylase<ref>PMID:1534690</ref>. | + | '''Phosphoribosylaminoimidazole carboxylase (PurE)''' is part of the purine biosynthesis and catalyses the reversible conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 5-aminoimidazole ribonucleotide (AIR). In ''E. coli'' PurE is an independent enzyme while in plants and fungi it is a domain of phosphoribosylaminoimidazole carboxylase<ref>PMID:1534690</ref>. |
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| + | == Structural highlights == | ||
| + | PurE active site is located in a cleft between 3 subunits<ref>PMID:10574791</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:35, 30 June 2016
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3D structures of PurE
Updated on 30-June-2016
References
- ↑ Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM. Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway. Biochemistry. 1992 Jun 2;31(21):5022-32. PMID:1534690
- ↑ Mathews II, Kappock TJ, Stubbe J, Ealick SE. Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway. Structure. 1999 Nov 15;7(11):1395-406. PMID:10574791
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