Plasminogen activator
From Proteopedia
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*'''Tissue PLA''' (TPA) which is involved in breakdown of blood clots and urokinase-type PLA [[Urokinase]]. | *'''Tissue PLA''' (TPA) which is involved in breakdown of blood clots and urokinase-type PLA [[Urokinase]]. | ||
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| + | == Relevance == | ||
| + | Treatment with tissue PLA for acute ischemic stroke is beneficial<ref>PMID:7477192</ref>. | ||
==3D structures of plasminogen activator== | ==3D structures of plasminogen activator== | ||
Revision as of 10:36, 4 July 2016
Plasminogen activator (PLA) is a serine protease which converts plasminogen to plasmin. TPA structure contains heavy and light chains (HC, LC). PLA is inhibited by PLA inhibitor 1 and 2.
- Tissue PLA (TPA) which is involved in breakdown of blood clots and urokinase-type PLA Urokinase.
Relevance
Treatment with tissue PLA for acute ischemic stroke is beneficial[1].
3D structures of plasminogen activator
Updated on 04-July-2016
References
- ↑ . Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995 Dec 14;333(24):1581-7. PMID:7477192 doi:http://dx.doi.org/10.1056/NEJM199512143332401
