Plasminogen activator

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'''Plasminogen activator''' (PLA) is a serine protease which converts plasminogen to plasmin. TPA structure contains heavy and light chains (HC, LC). PLA is inhibited by PLA inhibitor 1 and 2.
'''Plasminogen activator''' (PLA) is a serine protease which converts plasminogen to plasmin. TPA structure contains heavy and light chains (HC, LC). PLA is inhibited by PLA inhibitor 1 and 2.
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*'''Tissue PLA''' (TPA) which is involved in breakdown of blood clots and urokinase-type PLA [[Urokinase]].
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*'''Tissue PLA''' (TPA) which is involved in breakdown of blood clots and urokinase-type PLA [[Urokinase]].<br />
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*Coagulase/fibrinolysin is a plasminogen activator from ''Yersinia pestis'' which possesses coagulase activity is responsible for degradation of plasmid-coded outer membrane proteins<ref>PMID:2843471</ref>.
== Relevance ==
== Relevance ==

Revision as of 06:44, 5 July 2016

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Plasminogen activator (PLA) is a serine protease which converts plasminogen to plasmin. TPA structure contains heavy and light chains (HC, LC). PLA is inhibited by PLA inhibitor 1 and 2.

  • Tissue PLA (TPA) which is involved in breakdown of blood clots and urokinase-type PLA Urokinase.
  • Coagulase/fibrinolysin is a plasminogen activator from Yersinia pestis which possesses coagulase activity is responsible for degradation of plasmid-coded outer membrane proteins[1].

Relevance

Treatment with tissue PLA for acute ischemic stroke is beneficial[2].

3D structures of plasminogen activator

Updated on 05-July-2016


References

  1. ↑ Sodeinde OA, Sample AK, Brubaker RR, Goguen JD. Plasminogen activator/coagulase gene of Yersinia pestis is responsible for degradation of plasmid-encoded outer membrane proteins. Infect Immun. 1988 Oct;56(10):2749-52. PMID:2843471
  2. ↑ . Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995 Dec 14;333(24):1581-7. PMID:7477192 doi:http://dx.doi.org/10.1056/NEJM199512143332401

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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