Plasminogen activator
From Proteopedia
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*'''Tissue PLA''' (TPA) which is involved in breakdown of blood clots and urokinase-type PLA [[Urokinase]].<br /> | *'''Tissue PLA''' (TPA) which is involved in breakdown of blood clots and urokinase-type PLA [[Urokinase]].<br /> | ||
| - | *Coagulase/fibrinolysin is a plasminogen activator from ''Yersinia pestis'' which possesses coagulase activity is responsible for degradation of plasmid-coded outer membrane proteins<ref>PMID:2843471</ref>. | + | *'''Coagulase/fibrinolysin''' is a plasminogen activator from ''Yersinia pestis'' which possesses coagulase activity is responsible for degradation of plasmid-coded outer membrane proteins<ref>PMID:2843471</ref>. |
== Relevance == | == Relevance == | ||
Revision as of 06:45, 5 July 2016
Plasminogen activator (PLA) is a serine protease which converts plasminogen to plasmin. TPA structure contains heavy and light chains (HC, LC). PLA is inhibited by PLA inhibitor 1 and 2.
- Tissue PLA (TPA) which is involved in breakdown of blood clots and urokinase-type PLA Urokinase.
- Coagulase/fibrinolysin is a plasminogen activator from Yersinia pestis which possesses coagulase activity is responsible for degradation of plasmid-coded outer membrane proteins[1].
Relevance
Treatment with tissue PLA for acute ischemic stroke is beneficial[2].
3D structures of plasminogen activator
Updated on 05-July-2016
References
- ↑ Sodeinde OA, Sample AK, Brubaker RR, Goguen JD. Plasminogen activator/coagulase gene of Yersinia pestis is responsible for degradation of plasmid-encoded outer membrane proteins. Infect Immun. 1988 Oct;56(10):2749-52. PMID:2843471
- ↑ . Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995 Dec 14;333(24):1581-7. PMID:7477192 doi:http://dx.doi.org/10.1056/NEJM199512143332401
