Pre-mRNA-splicing factor

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{{STRUCTURE_3e9l| PDB=3e9l | SIZE=400| SCENE= |right|CAPTION=Human pre-mRNA-splicing factor 8 endonuclease domain complex with Na+ (purple) and Cl- (green) ions, [[3e9l]] }}
{{STRUCTURE_3e9l| PDB=3e9l | SIZE=400| SCENE= |right|CAPTION=Human pre-mRNA-splicing factor 8 endonuclease domain complex with Na+ (purple) and Cl- (green) ions, [[3e9l]] }}
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== Function ==
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'''Pre-mRNA-splicing factors (Prp)''' are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing<ref>PMID:10394358</ref>.
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'''Pre-mRNA-splicing factors (Prp)''' are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing. For details on pre-mRNA-splicing factors see<br />
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*'''Prp3b''' is part of the U2 small nuclear ribonucleoproteins complex (U2 snRNP)<br />
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*[[Prp8]]<br />
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*'''Prp8''' functions as a scaffold which mediates the ordered assembly of spliceosomal proteins and snRNAs. For details see [[Prp8]]<br />
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*[[Prp24]]<br />
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*'''Prp18''' and '''Bud31''' are essential for the catalytic step in pre-mRNA splicing process.<br />
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*'''snRNA-associated-splicing factor 24''' binds preferentially to the U4/U6 hybrid snRNAs. For details see [[Prp24]]<br />
*[[Prp19]]<br />
*[[Prp19]]<br />
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*[[Prp40]].
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*[[Prp40]].<br />
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*'''Prpcwc2''' is a yeast splicing factor which plays a role in the generation of a functional splicing center '''Prp RBM22''' is the human homolog of Prpcwc2.<br />
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*'''Prpcwc26''' or '''Bud13''' belongs to the pre-mRNA retention and splicing complex RES.<br />
== 3D Structures of pre-mRNA splicing factors ==
== 3D Structures of pre-mRNA splicing factors ==
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*Pre-mRNA-splicing factor 2
*Pre-mRNA-splicing factor 2
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**[[3beg]] – hPrp residues 105-219 + Ser/Thr-protein kinase – human<BR />
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**[[3beg]] – hPrp P33 subunit + Ser/Thr-protein kinase – human<BR />
**[[2o3d]] – hPrp P33 subunit
**[[2o3d]] – hPrp P33 subunit
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}}
}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:16, 10 July 2016

Template:STRUCTURE 3e9l

Function

Pre-mRNA-splicing factors (Prp) are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing[1].

  • Prp3b is part of the U2 small nuclear ribonucleoproteins complex (U2 snRNP)
  • Prp8 functions as a scaffold which mediates the ordered assembly of spliceosomal proteins and snRNAs. For details see Prp8
  • Prp18 and Bud31 are essential for the catalytic step in pre-mRNA splicing process.
  • snRNA-associated-splicing factor 24 binds preferentially to the U4/U6 hybrid snRNAs. For details see Prp24
  • Prp19
  • Prp40.
  • Prpcwc2 is a yeast splicing factor which plays a role in the generation of a functional splicing center Prp RBM22 is the human homolog of Prpcwc2.
  • Prpcwc26 or Bud13 belongs to the pre-mRNA retention and splicing complex RES.

3D Structures of pre-mRNA splicing factors

Updated on 10-July-2016



References

  1. ↑ Misteli T, Spector DL. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. Mol Cell. 1999 Jun;3(6):697-705. PMID:10394358

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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