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| - | | + | #REDIRECT [[5jyy]] This PDB entry is obsolete and replaced by 5jyy |
| - | ==Structure-Based Tetravalent Zanamivir with Potent Anti-influenza Activity==
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| - | <StructureSection load='5e6l' size='340' side='right' caption='[[5e6l]], [[Resolution|resolution]] 2.10Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5e6l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E6L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E6L FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5KU:(6R)-5-(ACETYLAMINO)-2,6-ANHYDRO-3,4,5-TRIDEOXY-4-[(DIAMINOMETHYLIDENE)AMINO]-6-[(11R,12S)-12,13-DIHYDROXY-9-OXO-2,5,10-TRIOXA-8-AZATRIDECAN-11-YL]-D-THREO-HEX-2-ENONIC+ACID'>5KU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mwl|4mwl]]</td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e6l OCA], [http://pdbe.org/5e6l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e6l RCSB], [http://www.ebi.ac.uk/pdbsum/5e6l PDBsum]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/R4NFR6_9INFA R4NFR6_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Exo-alpha-sialidase]]
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| - | [[Category: Bi, Y]]
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| - | [[Category: Fu, L]]
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| - | [[Category: Gao, G F]]
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| - | [[Category: Li, X]]
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| - | [[Category: Li, Y]]
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| - | [[Category: Lu, X]]
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| - | [[Category: Lv, X]]
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| - | [[Category: Qi, J]]
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| - | [[Category: Wu, Y]]
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| - | [[Category: Zhang, S]]
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| - | [[Category: Hydrolase-hydrolase inhibitor complex]]
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| - | [[Category: Na inhibitor]]
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| - | [[Category: Tetravalent zanamivir]]
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