5l5c
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Plexin A1 full extracellular region, domains 1 to 10, to 6 angstrom, spacegroup P4(3)2(1)2== | |
| - | + | <StructureSection load='5l5c' size='340' side='right' caption='[[5l5c]], [[Resolution|resolution]] 6.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5l5c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L5C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l5c OCA], [http://pdbe.org/5l5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l5c RCSB], [http://www.ebi.ac.uk/pdbsum/5l5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l5c ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PLXA1_MOUSE PLXA1_MOUSE]] Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Coles, C H]] | ||
| + | [[Category: Gilbert, R J.C]] | ||
| + | [[Category: Janssen, B J.C]] | ||
| + | [[Category: Jones, E Y]] | ||
| + | [[Category: Kaufmann, R]] | ||
| + | [[Category: Kong, Y]] | ||
| + | [[Category: Malinauskas, T]] | ||
| + | [[Category: Ni, T]] | ||
| + | [[Category: Padilla-Parra, S]] | ||
| + | [[Category: Pasterkamp, R J]] | ||
| + | [[Category: Vangoor, V R]] | ||
| + | [[Category: Axon guidance]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Signaling]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 18:05, 13 July 2016
Plexin A1 full extracellular region, domains 1 to 10, to 6 angstrom, spacegroup P4(3)2(1)2
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