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5bwo
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Human SIRT3 in Complex with a Palmitoyl H3K9 Peptide== | |
| - | + | <StructureSection load='5bwo' size='340' side='right' caption='[[5bwo]], [[Resolution|resolution]] 2.38Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5bwo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BWO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bwl|5bwl]], [[5bwn|5bwn]], [[5bwp|5bwp]], [[5bwq|5bwq]]</td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bwo OCA], [http://pdbe.org/5bwo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bwo RCSB], [http://www.ebi.ac.uk/pdbsum/5bwo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bwo ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Gai, W]] | [[Category: Gai, W]] | ||
[[Category: Jiang, H]] | [[Category: Jiang, H]] | ||
| + | [[Category: Liu, D]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Peptide-hydrolase complex]] | ||
Revision as of 11:41, 14 July 2016
Crystal Structure of Human SIRT3 in Complex with a Palmitoyl H3K9 Peptide
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