Pyruvate dehydrogenase kinase

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{{STRUCTURE_1jm6| PDB=1jm6 | SIZE=400| SCENE= |right|CAPTION=Rat pyruvate dehydrogenase kinase isozyme 2 dimer complex with ADP (stick model) and Mg+2 ion (green) [[1jm6]] }}
{{STRUCTURE_1jm6| PDB=1jm6 | SIZE=400| SCENE= |right|CAPTION=Rat pyruvate dehydrogenase kinase isozyme 2 dimer complex with ADP (stick model) and Mg+2 ion (green) [[1jm6]] }}
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== Function ==
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'''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites<ref>PMID:11486000</ref>.
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== Relevance ==
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Inhibition of PDK decreases the damage caused by heart ischemia and are used in diabetes and cancer patients<ref>PMID:17310282</ref><ref>PMID:23471124</ref>.
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'''Pyruvate dehydrogenase kinase''' (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites.
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==3D structures of pyruvate dehydrogenase kinase==
==3D structures of pyruvate dehydrogenase kinase==

Revision as of 10:04, 2 August 2016

Template:STRUCTURE 1jm6

Function

Pyruvate dehydrogenase kinase (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites[1].

Relevance

Inhibition of PDK decreases the damage caused by heart ischemia and are used in diabetes and cancer patients[2][3].

3D structures of pyruvate dehydrogenase kinase

Updated on 02-August-2016

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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