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1ken

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|PDB= 1ken |SIZE=350|CAPTION= <scene name='initialview01'>1ken</scene>, resolution 3.50&Aring;
|PDB= 1ken |SIZE=350|CAPTION= <scene name='initialview01'>1ken</scene>, resolution 3.50&Aring;
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|LIGAND= <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|ACTIVITY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ken FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ken OCA], [http://www.ebi.ac.uk/pdbsum/1ken PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ken RCSB]</span>
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[[Category: hemagglutinin]]
[[Category: hemagglutinin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:16:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:47:30 2008''

Revision as of 18:47, 30 March 2008

Image:1ken.gif


PDB ID 1ken

Drag the structure with the mouse to rotate
, resolution 3.50Å
Ligands: ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION


Overview

We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.

About this Structure

1KEN is a Protein complex structure of sequences from Influenza a virus and Mus musculus. Full crystallographic information is available from OCA.

Reference

An antibody that prevents the hemagglutinin low pH fusogenic transition., Barbey-Martin C, Gigant B, Bizebard T, Calder LJ, Wharton SA, Skehel JJ, Knossow M, Virology. 2002 Mar 1;294(1):70-4. PMID:11886266

Page seeded by OCA on Sun Mar 30 21:47:30 2008

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