5jvp
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==The neck-linker and alpha 7 helix of Homo sapiens CENP-E== | |
| - | + | <StructureSection load='5jvp' size='340' side='right' caption='[[5jvp]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5jvp]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JVP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JVP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr> | |
| - | [[ | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[Category: Phillips, R | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jv3|5jv3]], [[5jvm|5jvm]], [[5jvr|5jvr]], [[5jvs|5jvs]], [[5jvu|5jvu]], [[5jx1|5jx1]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jvp OCA], [http://pdbe.org/5jvp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jvp RCSB], [http://www.ebi.ac.uk/pdbsum/5jvp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jvp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CENPE_HUMAN CENPE_HUMAN]] Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end-directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule-dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle.<ref>PMID:7889940</ref> <ref>PMID:17535814</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Phillips, R K]] | ||
[[Category: Rayment, I]] | [[Category: Rayment, I]] | ||
| + | [[Category: Coiled-coil]] | ||
| + | [[Category: Kinesin]] | ||
| + | [[Category: Motor protein]] | ||
Revision as of 04:18, 4 August 2016
The neck-linker and alpha 7 helix of Homo sapiens CENP-E
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