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2y4j
From Proteopedia
(Difference between revisions)
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==MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH LACTATE== | ==MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH LACTATE== | ||
<StructureSection load='2y4j' size='340' side='right' caption='[[2y4j]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2y4j' size='340' side='right' caption='[[2y4j]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y4j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2y4j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43812 Atcc 43812]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2xw2 2xw2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y4J FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bo8|2bo8]], [[2bo6|2bo6]], [[2bo4|2bo4]], [[2bo7|2bo7]], [[2y4l|2y4l]], [[2y4k|2y4k]], [[2y4m|2y4m]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bo8|2bo8]], [[2bo6|2bo6]], [[2bo4|2bo4]], [[2bo7|2bo7]], [[2y4l|2y4l]], [[2y4k|2y4k]], [[2y4m|2y4m]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y4j RCSB], [http://www.ebi.ac.uk/pdbsum/2y4j PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4j OCA], [http://pdbe.org/2y4j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y4j RCSB], [http://www.ebi.ac.uk/pdbsum/2y4j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y4j ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MGS_RHOMR MGS_RHOMR]] Involved in the biosynthesis of the stress protectant 2-O-alpha-D-mannosyl glycerate (MG) which is produced in response to growth at supraoptimal temperature and salinity, and protects several enzymes against inactivation by temperature, freeze-drying and osmotic stress. Catalyzes the condensation of alpha-GDP-D-mannose (GDP-Man) with D-glycerate to produce alpha-mannosyl-D-glycerate. It is specific for GDP-Man, but it can also use alpha-GDP-D-glucose (GDP-Glc), beta-GDP-D-fuctose, alpha-UDP-D-mannose and alpha-UDP-D-glucose as sugar donors. It is specific for D-glycerate, but it can also use D-lactate and glycolate as sugar acceptors. This reaction occurs with a net retention of anomeric configuration; the newly formed glycosidic linkage has the same alpha configuration as the sugar donor.<ref>PMID:10585410</ref> <ref>PMID:15951819</ref> <ref>PMID:21288903</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2y4j" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Atcc 43812]] | ||
[[Category: Mannosyl-3-phosphoglycerate synthase]] | [[Category: Mannosyl-3-phosphoglycerate synthase]] | ||
| - | [[Category: Rhodothermus marinus]] | ||
[[Category: Barry, C S]] | [[Category: Barry, C S]] | ||
[[Category: Davies, G J]] | [[Category: Davies, G J]] | ||
Revision as of 07:35, 4 August 2016
MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH LACTATE
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