This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

4gu5

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Revision as of 12:06, 4 August 2016

Structure of Full-length Drosophila Cryptochrome

Structural highlights

4gu5 is a 2 chain structure with sequence from Drome. This structure supersedes the now removed PDB entry 3tvs. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Gene:	CG3772, cry (DROME)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CRY1_DROME] Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate. Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing.^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7] ^[8] ^[9]

References

↑ Emery P, So WV, Kaneko M, Hall JC, Rosbash M. CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell. 1998 Nov 25;95(5):669-79. PMID:9845369
↑ Okano S, Kanno S, Takao M, Eker AP, Isono K, Tsukahara Y, Yasui A. A putative blue-light receptor from Drosophila melanogaster. Photochem Photobiol. 1999 Jan;69(1):108-13. PMID:10063806
↑ Stanewsky R, Kaneko M, Emery P, Beretta B, Wager-Smith K, Kay SA, Rosbash M, Hall JC. The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell. 1998 Nov 25;95(5):681-92. PMID:9845370
↑ Egan ES, Franklin TM, Hilderbrand-Chae MJ, McNeil GP, Roberts MA, Schroeder AJ, Zhang X, Jackson FR. An extraretinally expressed insect cryptochrome with similarity to the blue light photoreceptors of mammals and plants. J Neurosci. 1999 May 15;19(10):3665-73. PMID:10233998
↑ Ceriani MF, Darlington TK, Staknis D, Mas P, Petti AA, Weitz CJ, Kay SA. Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science. 1999 Jul 23;285(5427):553-6. PMID:10417378
↑ Collins B, Mazzoni EO, Stanewsky R, Blau J. Drosophila CRYPTOCHROME is a circadian transcriptional repressor. Curr Biol. 2006 Mar 7;16(5):441-9. PMID:16527739 doi:S0960-9822(06)01043-8
↑ Berndt A, Kottke T, Breitkreuz H, Dvorsky R, Hennig S, Alexander M, Wolf E. A novel photoreaction mechanism for the circadian blue light photoreceptor Drosophila cryptochrome. J Biol Chem. 2007 Apr 27;282(17):13011-21. Epub 2007 Feb 12. PMID:17298948 doi:M608872200
↑ Gegear RJ, Casselman A, Waddell S, Reppert SM. Cryptochrome mediates light-dependent magnetosensitivity in Drosophila. Nature. 2008 Aug 21;454(7207):1014-8. doi: 10.1038/nature07183. Epub 2008 Jul 20. PMID:18641630 doi:10.1038/nature07183
↑ Hoang N, Schleicher E, Kacprzak S, Bouly JP, Picot M, Wu W, Berndt A, Wolf E, Bittl R, Ahmad M. Human and Drosophila cryptochromes are light activated by flavin photoreduction in living cells. PLoS Biol. 2008 Jul 1;6(7):e160. doi: 10.1371/journal.pbio.0060160. PMID:18597555 doi:10.1371/journal.pbio.0060160

1 Structural highlights
2 Function
3 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4gu5"

@@ Line 1: / Line 1: @@
 ==Structure of Full-length Drosophila Cryptochrome==
 <StructureSection load='4gu5' size='340' side='right' caption='[[4gu5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4gu5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3tvs 3tvs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GU5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4gu5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3tvs 3tvs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GU5 FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CG3772, cry ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CG3772, cry ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gu5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gu5 RCSB], [http://www.ebi.ac.uk/pdbsum/4gu5 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gu5 OCA], [http://pdbe.org/4gu5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gu5 RCSB], [http://www.ebi.ac.uk/pdbsum/4gu5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gu5 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 13: / Line 14: @@
 __TOC__
 </StructureSection>
-[[Category: Drosophila melanogaster]]
+[[Category: Drome]]
 [[Category: Crane, B R]]
 [[Category: Jones, A R]]

4gu5

From Proteopedia

Revision as of 12:06, 4 August 2016

Structure of Full-length Drosophila Cryptochrome

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox