This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3mkl
From Proteopedia
(Difference between revisions)
m (Protected "3mkl" [edit=sysop:move=sysop]) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_3mkl| PDB=3mkl | SCENE= }} | ||
| - | ===Crystal structure of DNA-binding transcriptional dual regulator from Escherichia coli K-12=== | ||
| - | == | + | ==Crystal structure of DNA-binding transcriptional dual regulator from Escherichia coli K-12== |
| - | [[3mkl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <StructureSection load='3mkl' size='340' side='right' caption='[[3mkl]], [[Resolution|resolution]] 2.15Å' scene=''> |
| - | [[Category: | + | == Structural highlights == |
| - | [[Category: Chang, C | + | <table><tr><td colspan='2'>[[3mkl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MKL FirstGlance]. <br> |
| - | [[Category: Clancy, S | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[Category: Joachimiak, A | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gadX, yhiX, b3516, JW3484 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mkl OCA], [http://pdbe.org/3mkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mkl RCSB], [http://www.ebi.ac.uk/pdbsum/3mkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mkl ProSAT]</span></td></tr> |
| - | [[Category: Mack, J | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GADX_ECOLI GADX_ECOLI]] Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA, gadB and gadC. Depending on the conditions (growth phase and medium), can repress gadW.<ref>PMID:11298273</ref> <ref>PMID:11976288</ref> <ref>PMID:12446650</ref> <ref>PMID:12730179</ref> <ref>PMID:14617649</ref> <ref>PMID:14702398</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mk/3mkl_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mkl ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ecoli]] | ||
| + | [[Category: Chang, C]] | ||
| + | [[Category: Clancy, S]] | ||
| + | [[Category: Joachimiak, A]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Mack, J]] | ||
[[Category: Dna-binding protein]] | [[Category: Dna-binding protein]] | ||
[[Category: Mcsg]] | [[Category: Mcsg]] | ||
| - | [[Category: | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
| - | + | ||
| - | + | ||
[[Category: Transcription regulator]] | [[Category: Transcription regulator]] | ||
[[Category: Transcriptional dual regulator]] | [[Category: Transcriptional dual regulator]] | ||
Current revision
Crystal structure of DNA-binding transcriptional dual regulator from Escherichia coli K-12
| |||||||||||
