This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3p0g
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Structure of a nanobody-stabilized active state of the beta2 adrenoceptor== | ==Structure of a nanobody-stabilized active state of the beta2 adrenoceptor== | ||
<StructureSection load='3p0g' size='340' side='right' caption='[[3p0g]], [[Resolution|resolution]] 3.50Å' scene=''> | <StructureSection load='3p0g' size='340' side='right' caption='[[3p0g]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3p0g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3p0g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. The April 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P0G FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [http://www.ebi.ac.uk/pdbsum/3p0g PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [http://pdbe.org/3p0g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [http://www.ebi.ac.uk/pdbsum/3p0g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0g ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| Line 18: | Line 19: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3p0g" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Adrenergic receptor|Adrenergic receptor]] | *[[Adrenergic receptor|Adrenergic receptor]] | ||
| - | *[[Antibody|Antibody]] | ||
*[[Lysozyme 3D structures|Lysozyme 3D structures]] | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | ||
| + | *[[3D structures of antibody|3D structures of antibody]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Camelus glama]] |
| - | [[Category: | + | [[Category: Human]] |
[[Category: Lysozyme]] | [[Category: Lysozyme]] | ||
[[Category: Nanobodies]] | [[Category: Nanobodies]] | ||
Revision as of 14:33, 4 August 2016
Structure of a nanobody-stabilized active state of the beta2 adrenoceptor
| |||||||||||
Categories: Camelus glama | Human | Lysozyme | Nanobodies | RCSB PDB Molecule of the Month | Casarosa, P | Chae, P S | Choi, H J | DeVree, B T | Fung, J J | Gellman, S H | Kobilka, B K | Kobilka, T S | Konetzki, I | Pardon, E | Pautsch, A | Rasmussen, S G.F | Rosenbaum, D M | Schnapp, A | Steyaert, J | Sunahara, R K | Thian, F S | Weis, W I | Agonist | Beta-2 adrenoceptor | Gpcr | Hydrolase | Membrane | Membrane protein | Nanobody | Signaling protein
