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3lpf
From Proteopedia
(Difference between revisions)
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==Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea== | ==Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea== | ||
<StructureSection load='3lpf' size='340' side='right' caption='[[3lpf]], [[Resolution|resolution]] 2.26Å' scene=''> | <StructureSection load='3lpf' size='340' side='right' caption='[[3lpf]], [[Resolution|resolution]] 2.26Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3lpf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3lpf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LPF FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Z77:1-[(6,7-DIMETHYL-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)METHYL]-1-(2-HYDROXYETHYL)-3-(3-METHOXYPHENYL)THIOUREA'>Z77</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Z77:1-[(6,7-DIMETHYL-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)METHYL]-1-(2-HYDROXYETHYL)-3-(3-METHOXYPHENYL)THIOUREA'>Z77</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3k4a|3k4a]], [[3k46|3k46]], [[3k4d|3k4d]], [[3lpg|3lpg]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3k4a|3k4a]], [[3k46|3k46]], [[3k4d|3k4d]], [[3lpg|3lpg]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b1617, gurA, gusA, JW1609, uidA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b1617, gurA, gusA, JW1609, uidA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucuronidase Beta-glucuronidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.31 3.2.1.31] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucuronidase Beta-glucuronidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.31 3.2.1.31] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lpf RCSB], [http://www.ebi.ac.uk/pdbsum/3lpf PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lpf OCA], [http://pdbe.org/3lpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lpf RCSB], [http://www.ebi.ac.uk/pdbsum/3lpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lpf ProSAT]</span></td></tr> |
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3lpf" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Glucuronidase|Glucuronidase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Beta-glucuronidase]] | [[Category: Beta-glucuronidase]] | ||
| - | [[Category: | + | [[Category: Ecoli]] |
[[Category: Redinbo, M R]] | [[Category: Redinbo, M R]] | ||
[[Category: Wallace, B D]] | [[Category: Wallace, B D]] | ||
Revision as of 15:10, 4 August 2016
Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea
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