1l6z
From Proteopedia
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|PDB= 1l6z |SIZE=350|CAPTION= <scene name='initialview01'>1l6z</scene>, resolution 3.32Å | |PDB= 1l6z |SIZE=350|CAPTION= <scene name='initialview01'>1l6z</scene>, resolution 3.32Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= Murine CEACAM1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= Murine CEACAM1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1hnf|1HNF]], [[1e4j|1E4J]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6z OCA], [http://www.ebi.ac.uk/pdbsum/1l6z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l6z RCSB]</span> | ||
}} | }} | ||
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[[Category: Zelus, B D.]] | [[Category: Zelus, B D.]] | ||
[[Category: Zhang, R.]] | [[Category: Zhang, R.]] | ||
| - | [[Category: NAG]] | ||
| - | [[Category: NDG]] | ||
[[Category: cea family]] | [[Category: cea family]] | ||
[[Category: cell adhesion]] | [[Category: cell adhesion]] | ||
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[[Category: ig-like domain]] | [[Category: ig-like domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:59:00 2008'' |
Revision as of 18:59, 30 March 2008
| |||||||
| , resolution 3.32Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | Murine CEACAM1A (Mus musculus) | ||||||
| Related: | 1HNF, 1E4J
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF MURINE CEACAM1A[1,4]: A CORONAVIRUS RECEPTOR AND CELL ADHESION MOLECULE IN THE CEA FAMILY
Overview
CEACAM1 is a member of the carcinoembryonic antigen (CEA) family. Isoforms of murine CEACAM1 serve as receptors for mouse hepatitis virus (MHV), a murine coronavirus. Here we report the crystal structure of soluble murine sCEACAM1a[1,4], which is composed of two Ig-like domains and has MHV neutralizing activity. Its N-terminal domain has a uniquely folded CC' loop that encompasses key virus-binding residues. This is the first atomic structure of any member of the CEA family, and provides a prototypic architecture for functional exploration of CEA family members. We discuss the structural basis of virus receptor activities of murine CEACAM1 proteins, binding of Neisseria to human CEACAM1, and other homophilic and heterophilic interactions of CEA family members.
About this Structure
1L6Z is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family., Tan K, Zelus BD, Meijers R, Liu JH, Bergelson JM, Duke N, Zhang R, Joachimiak A, Holmes KV, Wang JH, EMBO J. 2002 May 1;21(9):2076-86. PMID:11980704
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