4nfi
From Proteopedia
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==Crystal structure of human FPPS in complex with magnesium and JDS05120== | ==Crystal structure of human FPPS in complex with magnesium and JDS05120== | ||
<StructureSection load='4nfi' size='340' side='right' caption='[[4nfi]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='4nfi' size='340' side='right' caption='[[4nfi]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JD5:[({5-[4-(CYCLOPROPYLOXY)PHENYL]PYRIDIN-3-YL}AMINO)METHANEDIYL]BIS(PHOSPHONIC+ACID)'>JD5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JD5:[({5-[4-(CYCLOPROPYLOXY)PHENYL]PYRIDIN-3-YL}AMINO)METHANEDIYL]BIS(PHOSPHONIC+ACID)'>JD5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nfj|4nfj]], [[4nfk|4nfk]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nfj|4nfj]], [[4nfk|4nfk]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nfi RCSB], [http://www.ebi.ac.uk/pdbsum/4nfi PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfi OCA], [http://pdbe.org/4nfi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nfi RCSB], [http://www.ebi.ac.uk/pdbsum/4nfi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nfi ProSAT]</span></td></tr> |
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | [[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | ||
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| + | ==See Also== | ||
| + | *[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 20:43, 4 August 2016
Crystal structure of human FPPS in complex with magnesium and JDS05120
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