1ldp
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= H-2LD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= H-2LD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ldp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ldp OCA], [http://www.ebi.ac.uk/pdbsum/1ldp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ldp RCSB]</span> | ||
}} | }} | ||
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[[Category: Speir, J A.]] | [[Category: Speir, J A.]] | ||
[[Category: Wilson, I A.]] | [[Category: Wilson, I A.]] | ||
| - | [[Category: NDG]] | ||
[[Category: antigen presentation]] | [[Category: antigen presentation]] | ||
[[Category: antigen receptor]] | [[Category: antigen receptor]] | ||
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[[Category: peptide antigen]] | [[Category: peptide antigen]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:01:31 2008'' |
Revision as of 19:01, 30 March 2008
| |||||||
| , resolution 3.1Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | and | ||||||
| Ligands: | |||||||
| Gene: | H-2LD (Mus musculus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES
Overview
MHC class I H-2Ld complexed with peptide QL9 (or p2Ca) is a high-affinity alloantigen for the 2C TCR. We used the crystal structure of H-2Ld with a mixture of bound peptides at 3.1 A to construct a model of the allogeneic 2C-Ld/QL9 complex for comparison with the syngeneic 2C-Kb/dEV8 structure. A prominent ridge on the floor of the Ld peptide-binding groove, not present in Kb, creates a C-terminal bulge in Ld peptides that greatly increases interactions with the 2C beta-chain. Furthermore, weak electrostatic complementarity between Asp77 on the alpha1 helix of Kb and 2C is enhanced in the allogeneic complex by closer proximity of QL9 peptide residue AspP8 to the 2C HV4 loop.
About this Structure
1LDP is a Protein complex structure of sequences from Drosophila melanogaster and Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes., Speir JA, Garcia KC, Brunmark A, Degano M, Peterson PA, Teyton L, Wilson IA, Immunity. 1998 May;8(5):553-62. PMID:9620676
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