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3mpx

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{{Seed}}
 
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[[Image:3mpx.jpg|left|200px]]
 
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<!--
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==Crystal structure of the DH and PH-1 domains of human FGD5==
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The line below this paragraph, containing "STRUCTURE_3mpx", creates the "Structure Box" on the page.
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<StructureSection load='3mpx' size='340' side='right' caption='[[3mpx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mpx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MPX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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-->
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3mpx| PDB=3mpx | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FGD5, ZFYVE23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mpx OCA], [http://pdbe.org/3mpx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mpx RCSB], [http://www.ebi.ac.uk/pdbsum/3mpx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mpx ProSAT]</span></td></tr>
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===Crystal structure of the DH and PH-1 domains of human FGD5===
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/FGD5_HUMAN FGD5_HUMAN]] Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
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==About this Structure==
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== Evolutionary Conservation ==
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3MPX is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPX OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Homo sapiens]]
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Check<jmol>
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[[Category: Arrowsmith, C H.]]
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<jmolCheckbox>
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[[Category: Bochkarev, A.]]
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mp/3mpx_consurf.spt"</scriptWhenChecked>
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[[Category: Bountra, C.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Crombet, L.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Edwards, A M.]]
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</jmolCheckbox>
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[[Category: Nedyalkova, L.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mpx ConSurf].
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[[Category: Park, H.]]
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<div style="clear:both"></div>
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[[Category: SGC, Structural Genomics Consortium.]]
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__TOC__
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[[Category: Shen, Y.]]
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</StructureSection>
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[[Category: Tempel, W.]]
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[[Category: Human]]
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[[Category: Tong, Y.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Weigelt, J.]]
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[[Category: Bochkarev, A]]
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[[Category: Bountra, C]]
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[[Category: Crombet, L]]
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[[Category: Edwards, A M]]
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[[Category: Nedyalkova, L]]
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[[Category: Park, H]]
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[[Category: Structural genomic]]
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[[Category: Shen, Y]]
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[[Category: Tempel, W]]
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[[Category: Tong, Y]]
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[[Category: Weigelt, J]]
[[Category: Dh domain]]
[[Category: Dh domain]]
[[Category: Lipid binding protein]]
[[Category: Lipid binding protein]]
[[Category: Ph domain]]
[[Category: Ph domain]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:51:48 2010''
 

Current revision

Crystal structure of the DH and PH-1 domains of human FGD5

3mpx, resolution 2.80Å

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