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3mpx
From Proteopedia
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| - | {{STRUCTURE_3mpx| PDB=3mpx | SCENE= }} | ||
| - | ===Crystal structure of the DH and PH-1 domains of human FGD5=== | ||
| - | ==Function== | + | ==Crystal structure of the DH and PH-1 domains of human FGD5== |
| + | <StructureSection load='3mpx' size='340' side='right' caption='[[3mpx]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3mpx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MPX FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FGD5, ZFYVE23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mpx OCA], [http://pdbe.org/3mpx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mpx RCSB], [http://www.ebi.ac.uk/pdbsum/3mpx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mpx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/FGD5_HUMAN FGD5_HUMAN]] Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. | [[http://www.uniprot.org/uniprot/FGD5_HUMAN FGD5_HUMAN]] Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. | ||
| - | + | == Evolutionary Conservation == | |
| - | == | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[ | + | Check<jmol> |
| - | [[Category: | + | <jmolCheckbox> |
| - | [[Category: Arrowsmith, C H | + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mp/3mpx_consurf.spt"</scriptWhenChecked> |
| - | [[Category: Bochkarev, A | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[Category: Bountra, C | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[Category: Crombet, L | + | </jmolCheckbox> |
| - | [[Category: Edwards, A M | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mpx ConSurf]. |
| - | [[Category: Nedyalkova, L | + | <div style="clear:both"></div> |
| - | [[Category: Park, H | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Shen, Y | + | [[Category: Human]] |
| - | [[Category: Tempel, W | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Tong, Y | + | [[Category: Bochkarev, A]] |
| - | [[Category: Weigelt, J | + | [[Category: Bountra, C]] |
| + | [[Category: Crombet, L]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Nedyalkova, L]] | ||
| + | [[Category: Park, H]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Shen, Y]] | ||
| + | [[Category: Tempel, W]] | ||
| + | [[Category: Tong, Y]] | ||
| + | [[Category: Weigelt, J]] | ||
[[Category: Dh domain]] | [[Category: Dh domain]] | ||
[[Category: Lipid binding protein]] | [[Category: Lipid binding protein]] | ||
[[Category: Ph domain]] | [[Category: Ph domain]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomics consortium]] | ||
Current revision
Crystal structure of the DH and PH-1 domains of human FGD5
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Categories: Human | Arrowsmith, C H | Bochkarev, A | Bountra, C | Crombet, L | Edwards, A M | Nedyalkova, L | Park, H | Structural genomic | Shen, Y | Tempel, W | Tong, Y | Weigelt, J | Dh domain | Lipid binding protein | Ph domain | Sgc
