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3zrm
From Proteopedia
(Difference between revisions)
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==Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors== | ==Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors== | ||
<StructureSection load='3zrm' size='340' side='right' caption='[[3zrm]], [[Resolution|resolution]] 2.49Å' scene=''> | <StructureSection load='3zrm' size='340' side='right' caption='[[3zrm]], [[Resolution|resolution]] 2.49Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3zrm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3zrm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZRM FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZRM:7-(4-HYDROXYPHENYL)-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE'>ZRM</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZRM:7-(4-HYDROXYPHENYL)-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE'>ZRM</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uw9|2uw9]], [[1o6k|1o6k]], [[1h8f|1h8f]], [[1gng|1gng]], [[1q3w|1q3w]], [[3zrk|3zrk]], [[1i09|1i09]], [[2x37|2x37]], [[1o9u|1o9u]], [[1o6l|1o6l]], [[2jdr|2jdr]], [[1j1b|1j1b]], [[1r0e|1r0e]], [[1q41|1q41]], [[2x39|2x39]], [[1q3d|1q3d]], [[2jld|2jld]], [[1q5k|1q5k]], [[2jdo|2jdo]], [[1pyx|1pyx]], [[1q4l|1q4l]], [[1j1c|1j1c]], [[2xh5|2xh5]], [[1uv5|1uv5]], [[3zrl|3zrl]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uw9|2uw9]], [[1o6k|1o6k]], [[1h8f|1h8f]], [[1gng|1gng]], [[1q3w|1q3w]], [[3zrk|3zrk]], [[1i09|1i09]], [[2x37|2x37]], [[1o9u|1o9u]], [[1o6l|1o6l]], [[2jdr|2jdr]], [[1j1b|1j1b]], [[1r0e|1r0e]], [[1q41|1q41]], [[2x39|2x39]], [[1q3d|1q3d]], [[2jld|2jld]], [[1q5k|1q5k]], [[2jdo|2jdo]], [[1pyx|1pyx]], [[1q4l|1q4l]], [[1j1c|1j1c]], [[2xh5|2xh5]], [[1uv5|1uv5]], [[3zrl|3zrl]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Tau_protein]_kinase [Tau protein] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.26 2.7.11.26] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Tau_protein]_kinase [Tau protein] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.26 2.7.11.26] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zrm RCSB], [http://www.ebi.ac.uk/pdbsum/3zrm PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrm OCA], [http://pdbe.org/3zrm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zrm RCSB], [http://www.ebi.ac.uk/pdbsum/3zrm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zrm ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3zrm" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Bamborough, P]] | [[Category: Bamborough, P]] | ||
[[Category: Bax, B]] | [[Category: Bax, B]] | ||
Revision as of 21:39, 4 August 2016
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors
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Categories: Human | Bamborough, P | Bax, B | Bernasconi, G | Bridges, A | Brough, C | Carter, P | Cutler, G | Gentile, G | Marzorati, P | Merlo, G | Neu, M | Pozzan, A | Takada, M | Kinase | Transferase-peptide complex
