This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4b1f
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Design of Inhibitors of Helicobacter pylori Glutamate Racemase as Selective Antibacterial Agents: Incorporation of Imidazoles onto a Core Pyrazolopyrimidinedione Scaffold to Improve Bioavailabilty== | ==Design of Inhibitors of Helicobacter pylori Glutamate Racemase as Selective Antibacterial Agents: Incorporation of Imidazoles onto a Core Pyrazolopyrimidinedione Scaffold to Improve Bioavailabilty== | ||
<StructureSection load='4b1f' size='340' side='right' caption='[[4b1f]], [[Resolution|resolution]] 2.05Å' scene=''> | <StructureSection load='4b1f' size='340' side='right' caption='[[4b1f]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4b1f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4b1f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B1F FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=KRH:5-METHYL-3-(1-METHYL-1H-IMIDAZOL-5-YL)-7-(2-METHYLPROPYL)-2-(NAPHTHALEN-1-YLMETHYL)-2H-PYRAZOLO[3,4-D]PYRIMIDINE-4,6(5H,7H)-DIONE'>KRH</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=KRH:5-METHYL-3-(1-METHYL-1H-IMIDAZOL-5-YL)-7-(2-METHYLPROPYL)-2-(NAPHTHALEN-1-YLMETHYL)-2H-PYRAZOLO[3,4-D]PYRIMIDINE-4,6(5H,7H)-DIONE'>KRH</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jfx|2jfx]], [[2jfy|2jfy]], [[2jfz|2jfz]], [[2w4i|2w4i]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jfx|2jfx]], [[2jfy|2jfy]], [[2jfz|2jfz]], [[2w4i|2w4i]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b1f RCSB], [http://www.ebi.ac.uk/pdbsum/4b1f PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1f OCA], [http://pdbe.org/4b1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b1f RCSB], [http://www.ebi.ac.uk/pdbsum/4b1f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1f ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| Line 18: | Line 19: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4b1f" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| Line 25: | Line 27: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Atcc 43504]] | ||
[[Category: Glutamate racemase]] | [[Category: Glutamate racemase]] | ||
| - | [[Category: Helicobacter pylori]] | ||
[[Category: Basarab, G S]] | [[Category: Basarab, G S]] | ||
[[Category: Eyermanna, C J]] | [[Category: Eyermanna, C J]] | ||
Revision as of 23:06, 4 August 2016
Design of Inhibitors of Helicobacter pylori Glutamate Racemase as Selective Antibacterial Agents: Incorporation of Imidazoles onto a Core Pyrazolopyrimidinedione Scaffold to Improve Bioavailabilty
| |||||||||||
