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4hwo

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==Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor==
==Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor==
<StructureSection load='4hwo' size='340' side='right' caption='[[4hwo]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
<StructureSection load='4hwo' size='340' side='right' caption='[[4hwo]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hwo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hwo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=409:N-{[3-(4-AMINOQUINAZOLIN-7-YL)PHENYL]SULFONYL}-L-THREONINAMIDE'>409</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=409:N-{[3-(4-AMINOQUINAZOLIN-7-YL)PHENYL]SULFONYL}-L-THREONINAMIDE'>409</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hwp|4hwp]], [[4hwr|4hwr]], [[4hws|4hws]], [[4hwt|4hwt]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hwp|4hwp]], [[4hwr|4hwr]], [[4hws|4hws]], [[4hwt|4hwt]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thrS, b1719, JW1709 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thrS, b1719, JW1709 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hwo RCSB], [http://www.ebi.ac.uk/pdbsum/4hwo PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwo OCA], [http://pdbe.org/4hwo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hwo RCSB], [http://www.ebi.ac.uk/pdbsum/4hwo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4hwo" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli k-12]]
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[[Category: Ecoli]]
[[Category: Threonine--tRNA ligase]]
[[Category: Threonine--tRNA ligase]]
[[Category: Hilgers, M T]]
[[Category: Hilgers, M T]]

Revision as of 23:37, 4 August 2016

Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor

4hwo, resolution 1.91Å

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